Seok Hee Kim,1Jin Won Yang,2Kyung Han Kim,3Jong Uk Kim,1 and Tae Han Yook1,*
Published online 2019 Dec 31. doi: 10.3831/KPI.2019.22.030
The interest in senile disease is rising gradually because aging society has become a more common phenomenon. Types of dementia include AD, vascular dementia, paralytic dementia, Lewy body dementia, carbon monoxide induced dementia, and trauma dementia [1,2]. The onset of AD has continued to increase since 1995, while the prevalence of vascular dementia is gradually decreasing. Therefore, AD draws attention from researchers [3]. AD is a disease that is caused by the gradual degeneration and death of cerebral cortical cells. The main symptoms are memory loss, cognitive decline and behavioral disorders [4]. Histopathologically, overall encephalatrophy, senile plaques, and neurofibromatosis (NFT) are the common characteristics of AD [5]. Acquired cognitive deficits caused by AD have a significant impact on the social life and activity of the patients [6]. Moreover, active treatment of memory disorders greatly affects the prognosis of AD patients [3]. Consequently, many researchers acknowledge the need for a therapeutic drug to restore the memory and cognitive damages of AD patients, and various studies have been conducted.
“…The results of these studies confirmed that CBD activated the peroxisome proliferator-activated receptor-γ(PPARγ) through the Wnt/β-catenin pathway to protect PC12 cells from Aβ neurotoxicity and oxidation stress, increase cell survival, reduce ROS production, reduce lipid peroxidation, inhibit the hyperphosphirylation of tau protein, inhibit AChE, and stimulate the neurogenesis of the hippocampus.
Additionally, CBD+THC treatment to AβPP/PS1 transgenic mice revealed that CBD+THC treatment was effective in memory and CBD+THC treatment was more effective than CBD alone or THC alone treatment. These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone.
“…We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive tool. tool…”